Genomic Targets of Nuclear Estrogen Receptors
نویسندگان
چکیده
منابع مشابه
Genomic targets of nuclear estrogen receptors.
Estrogen influences the physiology of many target tissues in both women and men. The long-term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) functioning as DNA-binding transcription factors. Tissue-specific responses to estrogen therefore result from regulation of different sets of genes. However, it remains perplexing as to what regulatory sequence contexts...
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Members of this receptor family are related to each other in terms of their amino acid sequence and their function within cells. They therefore have structural features in common. These include a central highly conserved DNA binding domain and generally greater than 60% homology in the ligand binding domain (LBD). The quintessential characteristic of nuclear receptors, and the basis for the nam...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2004
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2003-0044